DTI-tech ~ Drug Target Identification

DTI-tech - Drug Target Identification

DTI-Tech is a privately held company offering services to academia and biotech and pharma companies.

Experienced researchers focus on the drug's target identification and on protein-protein interactions.

A soon as a small molecule demonstrate a certain activity against target cell lines, it is important to uncover its mechanism of action by using genomics and proteomics methods.

Gene expression profiling helps to identify the pathways affected by the small molecule but only more sophisticated proteomics approaches can provide the list of the drug's targets.

 

Proteomics approaches available for drug target identification:

1) Chemical proteomics: a modified small molecule used as bait for the fishing of its protein targets.

2) DARTS (Drug Affinity Responsive Target Stability) method: the binding of a small molecule with its protein targets protect the latter from enzymatic proteolysis.

3) TPP (Thermic proteome profile) method: the binding of a small molecule with its protein targets protect the latter from thermic degradation.

We find the protein targets
of your drug-like small molecule.

Eugenio Gaudio Francesco Paduano

Eugenio: Cancer researcher with more than 15 years of experience in the protein-protein interactions, synthesis of new anti-cancer agents (author of 3 patents) and development of new methods for drug target identification (winner of a SPARK grant on this topic). Research experience in the USA (Ohio State University) and in Switzerland (Institute of Oncology Research).

Francesco: With over 15 years of experience in molecular and cellular biology, regenerative medicine, stem cells biology and medical genetics, Francesco has the breadth and depth of experience needed to quickly understand and solve problems. Previously, Francesco held various positions in the National Cancer Institute and academic and non-academic centres in Italy. Francesco is author of 2 medical patents, co-author of more than 30 publications and three books.

Services as consultant

We offer the following services as consultant on the:

1) Identification of novel protein-protein interactions (PPIs).

2) Drug target identification by using proteomics methods (chemical proteomics, TPP, DARTS).

3) Drug discovery and preclinical research on anticancer agents.

Services as experimenters

We offer the following services as experimenters on the:

1) Drug target identification by using our innovative and original DTI-Tech Method.

2) Cell biology assays, such as drug screening, proliferation assays, and apoptosis assays, etc.

3) Molecular biology assays applied to proteins, DNA, and RNA, including plasmid cloning, ELISA, Western blotting, immunoprecipitations, etc.

Our DTI-Tech method is based on the principle that a small molecule affects the binding of its protein targets to an undisclosed resin very avid for proteins. Both small molecules and drug protein targets remain in their native status.

DTI-Tech Method

DTI-Tech is also developing its own small molecules for application in oncology. Few candidates are now in discovery and preclinical levels of evaluation.

pipeline-dtitech

September 14, 2024: DTI-Tech and ISBioLab (www.isbiolab.com) are proud to introduce a joint offering of an advanced drug target identification service, leveraging the innovative DTI-Tech method

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6500 Bellinzona
Switzerland
+41 (0)78 720 6609

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