DTI-Tech

DTI-Tech - Drug Target Identification

DTI-Tech is a privately held company offering services to academia and biotech and pharma companies.

Experienced researchers focus on the drug's target identification and on protein-protein interactions.

As soon as a small molecule demonstrates a certain activity against target cell lines, it is important to uncover its mechanism of action by using genomics and proteomics methods.

Gene expression profiling helps to identify the pathways affected by the small molecule but only more sophisticated proteomics approaches can provide the list of the drug's targets.

Proteomics approaches available for drug target identification:

1) Chemical proteomics: a modified small molecule used as bait for the fishing of its protein targets.

2) DARTS (Drug Affinity Responsive Target Stability) method: the binding of a small molecule with its protein targets protects the latter from enzymatic proteolysis.

3) TPP (Thermic proteome profile) method: the binding of a small molecule with its protein targets protects the latter from thermic degradation.

Services as consultant

We offer the following services as consultant on the:

1) Identification of novel protein-protein interactions (PPIs).

2) Drug target identification by using proteomics methods (chemical proteomics, TPP, DARTS).

3) Drug discovery and preclinical research on anticancer agents.

Services as experimenters

We offer the following services as experimenters on the:

1) Drug target identification by using our innovative and original DTI-Tech Method.

2) Cell biology assays, such as drug screening, proliferation assays, and apoptosis assays, etc.

3) Molecular biology assays applied to proteins, DNA, and RNA, including plasmid cloning, ELISA, Western blotting, immunoprecipitations, etc.